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Study estimates 75% of NFL players who died over 15-year span had CTE

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A study in JAMA Network Open estimates that nearly 75% of former NFL players who died between 2008 and 2023 had chronic traumatic encephalopathy (CTE), a brain disease linked to repeated head impacts. Researchers combined findings from 396 donated brains with death-record data on 1,966 other former players, then adjusted for the likelihood that families of players with cognitive symptoms were more likely to donate a brain. About 93% of the donated brains showed CTE signs; after adjustment, the team estimated that roughly 1,760 of the 2,360 players in the study had the disease. The estimate is three times higher than the same group’s earlier estimate for a five-year period. The researchers also estimated that 27% of the players had dementia.

The figure is not a direct count: CTE can currently be confirmed only after death, and the vast majority of players in the analysis did not have donated brains examined. Moreover, signs of CTE do not always lead to cognitive decline or other symptoms, and some autopsies may show limited brain changes. Experts say CTE can cause memory problems, mood changes and other difficulties, but similar symptoms occur in other conditions. Because the disease cannot yet be diagnosed in living people, the findings are estimates rather than a measure of confirmed cases. Researchers and clinicians point to reducing repeated head impacts as a key prevention strategy; NFL measures include helmet redesigns and kickoff rules intended to lower collision speeds.

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