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Blood cells from 80-year-old donor become stem cells with molecular age under 20

doi.org131 points86 comments
Screenshot of Blood cells from 80-year-old donor become stem cells with molecular age under 20

Commenters reacted to the paper with a mix of excitement, technical curiosity, and practical self-interest. ympb121 said the finding motivated healthier habits in hopes of living to benefit from future longevity therapies, and taneq compared the approach to the immortal jellyfish reset. Inshard pointed to Michael Levin’s bioelectricity work as relevant, while bitwize and EA-3167 warned about cancer risk - bitwize noted that full Yamanaka-factor activation can cause “turbo cancer” but claimed partial factor use can revert cells without that risk. Others flagged biological pitfalls (mullingitover), suggested AI could change the picture (deadbabe), and shared accessible summaries or videos (neom).

Debate split sharply over social and ethical implications. Layer8, sgnelson, robwwilliams and malloryerik worried that long-lived leaders or Baby Boomers would entrench power, while Loughla, yieldcrv and axus predicted the ultra-wealthy would monopolize treatments and push for regulatory havens. Some commenters invoked evolutionary or philosophical objections - moralestapia and robwwilliams framed aging as a feature, TedDoesntTalk cited literature on the curse of immortality - whereas torben-friis suggested longer-lived leaders might plan farther ahead and card_zero argued for deliberate political change instead of relying on mortality as a tool. Others reminded that accidents and external risks (skissane, idle_zealot) would still limit individual lifespans.

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