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The 2026 prize is awarded jointly to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” Hegemann and Nagel identified channelrhodopsin, a light-sensitive algal protein that confers light responsiveness when expressed in diverse cells. Deisseroth introduced the channelrhodopsin gene into rat neurons and, by illuminating them with blue light, triggered nerve signals, later demonstrating control of neurons in living mouse brains. That combination - discovery of light-gated ion channels and their genetic application to switch individual nerve cells on and off - established optogenetics as a powerful, widely adopted method for probing how brains generate memories, emotions and behaviors.
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