Super El Niño Keeps Growing as New Forecasts Reach Record Territory Ahead Winter and Abdominal Fat Predicts Heart Disease Risk Better Than BMI
First things first
Stuff’s getting wild out there - from crazy weather forecasts to AI experiments that only know what a fifth grader does. We’ve got stories on everything from the latest in climate weirdness and health insights to tech’s ongoing struggle with coordination and old-school coding habits. Plus, some bizarre twists in research, politics, and even ship navigation. Just another day in the chaos, right?
The top 6
Abdominal Fat Predicts Heart Disease Risk Better Than BMI
Software Engineering fundamentals matter more
Claude: System Prompts
What happens when an LLM never sees material beyond fifth grade?
Firefox for iOS now has a native adblocker
Quote of the day
Premature optimization is the root of all evil.
Donald Knuth
Also big today
Cultivating a state of mind where new ideas are born
Patterns and problems in emerging multi-agent systems
Research papers using "kidney disappointment" instead of "kidney failure"
Engineers will do anything to avoid learning from history
So How Is AI Drug Discovery Doing, Really?
AI drug discovery integrates machine learning with chemistry and biology to speed up target identification, virtual screening, molecule generation, and prediction of ADMET properties. Computational models reduce the search space and highlight candidates faster, but translating computational hits into clinically approved, safe drugs requires experimental validation and faces major scientific and regulatory hurdles.
The Government Is Monitoring Anti-Flock TikTok and Instagram Accounts
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Ask HN: Do you know of any company that went back to hand-written code?
The AI Credit Resale Economy
Credit card debt rises to $1.26T, nearing all-time record
Tracking down a Zsh history data loss bug
A U.S. Strategy to Prevent the Creation of Mirror Life
The Iran War Is a Whole New Level of Quagmire for the US
Song of the day
Deep cuts
St Lucie Nuclear Reactor Unit 1 manually shutdown, 3 control rods drop into core
The weekend is 100 years old
Guiding Ships with Moire Patterns
Banned Words List
Show HN: Laptop is the last place your secrets are still in plaintext
Government sponsored study on alcohol doesn't stand up to scrutiny: Nassim Taleb
Nassim Taleb criticizes a government-commissioned study claiming low to moderate alcohol consumption has no health benefits, citing flawed methodology and suspicious statistical analysis. He argues the study's conclusions are unreliable due to inconsistent confidence intervals, poor data handling, and reliance on highly uncertain data segments.